|
T36696 |
DMBA
|
|
|
|
7,12-Dimethylbenz[a]anthracene (DMBA) is a polycyclic aromatic hydrocarbon (PAH) that has been found in tobacco smoke and diesel exhaust and has carcinogenic activity.1,2It undergoes metabolic activation by numerous enzy... |
|
T37278 |
2-chloro Stearic Acid
|
|
|
|
2-chloro Stearic acid is a bioactive fatty acid that accumulates in primary human monocytes and neutrophils as well as murine neutrophils stimulated with phorbol 12-myristate 13-acetate . It induces DNA release from prim... |
|
T36412 |
Multiflorenol
|
|
|
|
Multiflorenol is a triterpene that has been found in T. kirilowii seeds.1 It inhibits in vitro activation of Epstein-Barr virus early antigen (EBV-EA) induced by the tumor promoter phorbol 12-myristate 13-acetate in a co... |
|
T37983 |
GM 1489
|
|
|
|
GM 1489 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with Ki values of 0.002, 0.1, 0.5, 0.2, and 20 μM for MMP-1, MMP-8, MMP-2, MMP-9, and MMP-3, respectively. It reduces 5-aza-2'-deoxycytidine-induc... |
|
T36320 |
C6 L-threo Ceramide (d18:1/6:0)
|
C6 L-threo Ceramide (d18:1/6:0) |
|
|
C6 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides., C6 L-threo Ceramide is cytotoxic to U937 cells in vitro (IC50 = 18 μM). It is metabolically inactive and, unlik... |
|
T81451 |
PKCd (8-17)
|
|
|
|
PKCd (8-17) is a bioactive peptide originating from the V1 domain of protein kinase C (PKC)d. It impedes phorbol 12-myristate 13-acetate (PMA)-stimulated PKCd translocation and activation, which mitigates ischemic injury... |
|
T37565 |
C6 D-threo Ceramide (d18:1/6:0)
|
C6 D-threo Ceramide (d18:1/6:0) |
|
|
C6 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides., C6 D-threo Ceramide is cytotoxic to U937 cells in vitro (IC50 = 18 μM). It is metabolically inactive and, unlik... |
|
T37564 |
C4 Ceramide (d18:1/4:0)
|
C4 Ceramide (d18:1/4:0),Cer(d18:1/4:0) |
|
|
C4 Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. [1] [2] [3] It inhibits IL-4 production by 16% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used... |
|
T69244 |
Betulonaldehyde
|
|
|
|
Betulonaldehyde is a pentacyclic triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin that has been found in Betula. It is active against P. falciparum (IC50 = 3.36 µg/ml) and cytotoxic to NCI H1... |
|
T35927 |
C2 L-threo Ceramide (d18:1/2:0)
|
C2 L-threo Ceramide (d18:1/2:0) |
|
|
C2 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor when used at a concentration o... |
|
T36235 |
5-Chlorouracil
|
|
|
|
5-Chlorouracil is a chlorinated derivative of the pyrimidine nucleoside base uracil . In vivo, it is converted into chlorodeoxyuridine, which is mutagenic and genotoxic.1 Uracil is chlorinated at the 5 position in a cell... |
|
T37439 |
C18 Globotriaosylceramide (d18:1/18:0)
|
|
|
|
C18 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from lactosylceramide . It inhibits aggregation of human neutrophils induced by phorbol 12-myristate 13-acetat... |
|
T83728 |
Tat-AKAP79 (326-336) TFA
|
Tat-A-kinase Anchor Protein 79 (326-336) |
|
|
Tat-AKAP79 (326-336) is a peptide that links the HIV-1 Tat protein transduction domain with an 11-amino acid sequence from A-kinase anchor protein 79 (AKAP79). This compound effectively inhibits the activation-induced se... |
|
T83701 |
TRPV1-Tat TFA
|
Transient Receptor Potential Vanilloid 1-Tat,736-745-Tat |
|
|
TRPV1-Tat, a peptide antagonist targeting transient receptor potential vanilloid 1 (TRPV1), is composed of amino acids 736-745 derived from TRPV1's A-kinase anchor protein (AKAP)-binding domain, combined with the HIV Tat... |
|
T36221 |
2-chloro Palmitic Acid
|
|
|
|
2-chloro Palmitic acid is a monochlorinated form of palmitic acid . It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate . 2-chloro Palmitic aci... |
